Article
Genome-wide association studies in pharmacogenomics: successes and lessons.
Pharmacogenetics and genomics - 1 Aug 2013
Motsinger-Reif Alison A, Jorgenson Eric, Relling Mary V, Kroetz Deanna L, Weinshilboum Richard, Cox Nancy J, Roden Dan M
Abstract excerpt
OBJECTIVE: As genotyping technology has progressed, genome-wide association studies (GWAS) have matured into efficient and effective tools for mapping genes underlying human phenotypes. METHODS: Recent studies have shown the utility of the GWAS approach for examining pharmacogenomic traits, including drug metabolism, efficacy, and toxicity. RESULTS: Application of GWAS to pharmacogenomic outcomes presents unique...
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