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Aurantiamide acetate suppresses the growth of malignant gliomas <i>in vitro</i> and <i>in vivo</i> by inhibiting autophagic flux

20 Feb 2015

Abstract excerpt

We aim to investigate the effect of aurantiamide acetate isolated from the aerial parts of Clematis terniflora DC against gliomas. Human malignant glioma U87 and U251 cells were incubated with different concentrations (0-100 μM) of aurantiamide acetate. Aurantiamide acetate greatly decreased the cell viability in a dose- and time-dependent manner. It induced moderate mitochondrial fragmentation and the loss of...

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PMID: 25704599
DOI: 10.1111/jcmm.12498

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