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Article

Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells

20 Feb 2015

Abstract excerpt

The association of Epstein-Barr virus (EBV) with plasmacytoid malignancies is now well established but how the virus influences microRNA expression in such cells is not known. We have used multiple myeloma (MM) cell lines to address this issue and find that an oncomiR, miR-21 is induced after in vitro EBV infection. The PU.1 binding site in miR-21 promoter was essential for its activation by the virus. In...

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PMID: 25704079
DOI: 10.1002/ijc.29489

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