Article
The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals.
The Journal of infectious diseases - 15 Aug 2015
Perkins Molly R, Bartha Istvan, Timmer J Katherina, Liebner Julia C, Wolinsky David, Wollinsky David, Günthard Huldrych F, Hauser Christoph, Bernasconi Enos, Hoffmann Matthias, Calmy Alexandra, Battegay Manuel, Telenti Amalio, Douek Daniel C, Fellay Jacques
Abstract excerpt
Systemic immune activation, a major determinant of human immunodeficiency virus (HIV) disease progression, is the result of a complex interplay between viral replication, dysregulation of the immune system, and microbial translocation due to gut mucosal damage. Although human genetic variants influencing HIV load have been identified, it is unknown how much the host genetic background contributes to...
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