Article
Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial.
British journal of cancer - 18 Feb 2014
Wevers M R, Aaronson N K, Verhoef S, Bleiker E M A, Hahn D E E, Kuenen M A, van der Sanden-Melis J, Brouwer T, Hogervorst F B L, van der Luijt R B, Valdimarsdottir H B, van Dalen T, Theunissen E B M, van Ooijen B, de Roos M A, Borgstein P J, Vrouenraets B C, Vriens E, Bouma W H, Rijna H, Vente J P, Witkamp A J, Rutgers E J T, Ausems M G E M
Abstract excerpt
BACKGROUND: Female breast cancer patients with a BRCA1/2 mutation have an increased risk of contralateral breast cancer. We investigated the effect of rapid genetic counselling and testing (RGCT) on choice of surgery. METHODS: Newly diagnosed breast cancer patients with at least a 10% risk of a BRCA1/2 mutation were randomised to an intervention group (offer of RGCT) or a control group (usual care; ratio 2 : 1)....
Topics
- Adult
- Aged
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Choice Behavior
- Female
- Genetic Counseling