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Article

Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis.

ASN neuro - 1 Jan 2000

Heinecke Karie A, Luoma Adrienne, d'Azzo Alessandra, Kirschner Daniel A, Seyfried Thomas N

Abstract excerpt

GM1-gangliosidosis is a glycosphingolipid lysosomal storage disease involving accumulation of GM1 and its asialo form (GA1) primarily in the brain. Thin-layer chromatography and X-ray diffraction were used to analyze the lipid content/composition and the myelin structure of the optic and sciatic nerves from 7- and 10-month old β-galactosidase (β-gal) +/? and β-gal -/- mice, a model of GM1gangliosidosis. Optic...

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Identifiers

PMID: 25694553
DOI: 10.1177/1759091415568913
PMCID: PMC4342369

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