Article
Genetic etiology of renal agenesis: fine mapping of Renag1 and identification of Kit as the candidate functional gene.
PloS one - 1 Jan 2015
Samanas Nyssa Becker, Commers Tessa W, Dennison Kirsten L, Harenda Quincy Eckert, Kurz Scott G, Lachel Cynthia M, Wavrin Kristen Leland, Bowler Michael, Nijman Isaac J, Guryev Victor, Cuppen Edwin, Hubner Norbert, Sullivan Ruth, Vezina Chad M, Shull James D
Abstract excerpt
Congenital anomalies of the kidney and urogenital tract (CAKUT) occur in approximately 0.5% of live births and represent the most frequent cause of end-stage renal disease in neonates and children. The genetic basis of CAKUT is not well defined. To understand more fully the genetic basis of one type of CAKUT, unilateral renal agenesis (URA), we are studying inbred ACI rats, which spontaneously exhibit URA and...
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