Article
Iron oxide nanoparticle-mediated development of cellular gap junction crosstalk to improve mesenchymal stem cells' therapeutic efficacy for myocardial infarction.
ACS nano - 24 Mar 2015
Han Jin, Kim Bokyoung, Shin Jung-Youn, Ryu Seungmi, Noh Myungkyung, Woo Jongsu, Park Jin-Sil, Lee Youjin, Lee Nohyun, Hyeon Taeghwan, Choi Donghoon, Kim Byung-Soo
Abstract excerpt
Electrophysiological phenotype development and paracrine action of mesenchymal stem cells (MSCs) are the critical factors that determine the therapeutic efficacy of MSCs for myocardial infarction (MI). In such respect, coculture of MSCs with cardiac cells has windowed a platform for cardiac priming of MSCs. Particularly, active gap junctional crosstalk of MSCs with cardiac cells in coculture has been known to...
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