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Detection of Leprosy in Ancient Human Skeletal Remains by Molecular Identification of Mycobacterium leprae

1 Sept 2000

Abstract excerpt

We isolated ancient DNA from skeletal remains obtained from a South German ossuary (approximately 1400-1800 AD) and from a 10th century Hungarian cemetery partially indicating macromorphologic evidence of leprosy. In samples taken of 2 skulls from Germany and of 1 hard palate from Hungary, Mycobacterium leprae-specific fragments of RLEP1 and RLEP3 were amplified using polymerase chain reaction (PCR), thereby...

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PMID: 10989644
DOI: 10.1093/ajcp/114.3.428

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