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Article

A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

1 Feb 2015

Abstract excerpt

Interferon-stimulated genes (ISGs) act in concert to provide a tight barrier against viruses. Recent studies have shed light on the contribution of individual ISG effectors to the antiviral state, but most have examined those acting on early, intracellular stages of the viral life cycle. Here, we applied an image-based screen to identify ISGs inhibiting late stages of influenza A virus (IAV) infection. We...

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Identifiers

PMID: 25679759
DOI: 10.1016/j.cell.2015.01.040

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