Hepatic steatosis in Wilson disease--Role of copper and PNPLA3 mutations.

doi:10.1016/j.jhep.2015.01.034

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Article

Hepatic steatosis in Wilson disease--Role of copper and PNPLA3 mutations.

Journal of hepatology - 1 Jul 2015

Stättermayer Albert Friedrich, Traussnigg Stefan, Dienes Hans-Peter, Aigner Elmar, Stauber Rudolf, Lackner Karoline, Hofer Harald, Stift Judith, Wrba Friedrich, Stadlmayr Andreas, Datz Christian, Strasser Michael, Maieron Andreas, Trauner Michael, Ferenci Peter

Abstract excerpt

BACKGROUND & AIMS: The earliest characteristic alterations of the liver pathology in Wilson disease (WD) include steatosis, which is sometimes indistinguishable from non-alcoholic fatty liver disease (NAFLD). Steatosis in WD may reflect copper-induced mitochondrial dysfunction. A genetic polymorphism in rs738409, in the patatin-like phospholipase domain-containing 3 gene (PNPLA3), is strongly associated with...

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PMID: 25678388
DOI: 10.1016/j.jhep.2015.01.034

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PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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