Article
Low hepatic copper content and PNPLA3 polymorphism in non-alcoholic fatty liver disease in patients without metabolic syndrome.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) - 1 Jan 2017
Stättermayer Albert Friedrich, Traussnigg Stefan, Aigner Elmar, Kienbacher Christian, Huber-Schönauer Ursula, Steindl-Munda Petra, Stadlmayr Andreas, Wrba Friedrich, Trauner Michael, Datz Christian, Ferenci Peter
Abstract excerpt
INTRODUCTION: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is multifactorial including metabolic, genetic (e.g. PNPLA3 [patatin-like phospholipase domain-containing 3 gene]), viral factors and drugs. Besides, there is evidence for a role of copper deficiency. Aim of the study was to evaluate the role of hepatic copper content, PNPLA3 in NAFLD patients with and without metabolic syndrome (MetS)....
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