Article
Gut virome sequencing in children with early islet autoimmunity.
Diabetes care - 1 May 2015
Kramná Lenka, Kolářová Kateřina, Oikarinen Sami, Pursiheimo Juha-Pekka, Ilonen Jorma, Simell Olli, Knip Mikael, Veijola Riitta, Hyöty Heikki, Cinek Ondrej
Abstract excerpt
OBJECTIVE: This study used next-generation sequencing (NGS) technologies to characterize the gut virome at the onset of islet autoimmunity. RESEARCH DESIGN AND METHODS: We conducted a case-control study nested within the Finnish Diabetes Prediction and Prevention (DIPP) cohort. The stool virome in 19 case children, who turned islet autoantibody positive before the age of 2 years and later developed clinical type...
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