Article
Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.
Diabetologia - 1 Mar 2017
Honkanen Hanna, Oikarinen Sami, Nurminen Noora, Laitinen Olli H, Huhtala Heini, Lehtonen Jussi, Ruokoranta Tanja, Hankaniemi Minna M, Lecouturier Valérie, Almond Jeffrey W, Tauriainen Sisko, Simell Olli, Ilonen Jorma, Veijola Riitta, Viskari Hanna, Knip Mikael, Hyöty Heikki
Abstract excerpt
AIMS/HYPOTHESIS: This case-control study was nested in a prospective birth cohort to evaluate whether the presence of enteroviruses in stools was associated with the appearance of islet autoimmunity in the Type 1 Diabetes Prediction and Prevention study in Finland. METHODS: Altogether, 1673 longitudinal stool samples from 129 case children who turned positive for multiple islet autoantibodies and 3108 stool...
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