Article
Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.
Diabetologia - 1 Jan 2018
Viskari Hanna, Oikarinen Sami, Hoppu Sanna, Vuorinen Tytti, Huhtala Heini, Toppari Jorma, Veijola Riitta, Ilonen Jorma, Knip Mikael, Hyöty Heikki
Abstract excerpt
AIMS/HYPOTHESIS: Animal and human studies have implied that enterovirus infections may modulate the risk of islet autoimmunity and type 1 diabetes. We set out to assess whether serial administration of live oral poliovirus vaccine (OPV) in early life can influence the initiation of islet autoimmunity in a cohort of genetically predisposed children. METHODS: OPV was administered to 64 children and a further 251...
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