Article
Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jul 2017
Zhao Guoyan, Vatanen Tommi, Droit Lindsay, Park Arnold, Kostic Aleksandar D, Poon Tiffany W, Vlamakis Hera, Siljander Heli, Härkönen Taina, Hämäläinen Anu-Maaria, Peet Aleksandr, Tillmann Vallo, Ilonen Jorma, Wang David, Knip Mikael, Xavier Ramnik J, Virgin Herbert W
Abstract excerpt
Viruses have long been considered potential triggers of autoimmune diseases. Here we defined the intestinal virome from birth to the development of autoimmunity in children at risk for type 1 diabetes (T1D). A total of 220 virus-enriched preparations from serially collected fecal samples from 11 children (cases) who developed serum autoantibodies associated with T1D (of whom five developed clinical T1D) were...
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