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Article

Blood outgrowth endothelial cells reduce hypoxia-mediated fibroblast to myofibroblast conversion by decreasing proangiogenic cytokines.

Journal of vascular research - 1 Jan 2014

Nieves Torres Evelyn C, Yang Binxia, Brahmbhatt Akshaar, Mukhopadhyay Debabrata, Misra Sanjay

Abstract excerpt

PURPOSE: Hypoxic conditions cause fibroblasts to differentiate into alpha smooth-muscle cell actin (α -SMA)-positive cells, i.e. myofibroblasts. This process is a hallmark of venous neointimal hyperplasia (VNH) associated with hemodialysis vascular access. The purpose of this study was to determine if blood outgrowth endothelial cells (BOEC) may reduce the conversion of fibroblasts into myofibroblasts under...

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Identifiers

PMID: 25677750
DOI: 10.1159/000369929
PMCID: PMC4376323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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