Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015

Zhang Xiao-Dong, Lee Jeong-Han, Lv Ping, Chen Wei Chun, Kim Hyo Jeong, Wei Dongguang, Wang Wenying, Sihn Choong-Ryoul, Doyle Karen Jo, Rock Jason R, Chiamvimonvat Nipavan, Yamoah Ebenezer N

Abstract excerpt

The developmental rehearsal for the debut of hearing is marked by massive changes in the membrane properties of hair cells (HCs) and spiral ganglion neurons (SGNs). Whereas the underlying mechanisms for the developing HC transition to mature stage are understood in detail, the maturation of SGNs from hyperexcitable prehearing to quiescent posthearing neurons with broad dynamic range is unknown. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Anoctamins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calcium

Share to Chloride Channels

Share to Chlorides

Share to Hearing

Share to Membrane Potentials

Share to Symporters

Source

Open in PubMed Open full text

Identifiers

PMID: 25675481
DOI: 10.1073/pnas.1414741112
PMCID: PMC4345570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A.PMID 25675481Read ↗

Association of the Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses.Semantic proximity Read ↗

Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.Semantic proximity Read ↗

Functional and developmental changes in the inner hair cell ribbon synapses caused by Myosin VI knockout and deafness-inducing point mutationSemantic proximity Read ↗

Kv4, Kv2, and Kv3 currents shape intrinsic lateral olivocochlear excitability independent of hair cell dysfunction during development and ageingSemantic proximity Read ↗

Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing loss.Semantic proximity Read ↗

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System.Semantic proximity Read ↗

Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Semantic proximity Read ↗

Gating of hair cell Ca <sup>2+</sup> channels governs the activity of cochlear neuronsSemantic proximity Read ↗

Gap junctions and cochlear homeostasis.Semantic proximity Read ↗

Indispensable Role of Ion Channels and Transporters in the Auditory System.Semantic proximity Read ↗

Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.Semantic proximity Read ↗

Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner ear.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.