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Article

[Susceptibility gene in multiple system atrophy (MSA)].

Rinsho shinkeigaku = Clinical neurology - 1 Jan 2014

Tsuji Shoji

Abstract excerpt

To elucidate molecular bases of multiple system atrophy (MSA), we first focused on recently identified MSA multiplex families. Though linkage analyses followed by whole genome resequencing, we have identified a causative gene, COQ2, for MSA. We then conducted comprehensive nucleotide sequence analysis of COQ2 of sporadic MSA cases and controls, and found that functionally deleterious COQ2 variants confer a strong...

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Source

Identifiers

PMID: 25672683
DOI: 10.5692/clinicalneurol.54.969

Genes

COQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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