Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment Response in Advanced Lung Adenocarcinomas with G719X/L861Q/S768I Mutations.

doi:10.1097/JTO.0000000000000504

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Article

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment Response in Advanced Lung Adenocarcinomas with G719X/L861Q/S768I Mutations.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2015

Chiu Chao-Hua, Yang Cheng-Ta, Shih Jin-Yuan, Huang Ming-Shyan, Su Wu-Chou, Lai Ruay-Sheng, Wang Chin-Chou, Hsiao Shih-Hsin, Lin Yu-Ching, Ho Ching-Liang, Hsia Te-Chun, Wu Ming-Fang, Lai Chun-Liang, Lee Kang-Yun, Lin Chih-Bin, Yu-Wung Yeh Diana, Chuang Chi-Yuan, Chang Fu-Kang, Tsai Chun-Ming, Perng Reury-Perng, Chih-Hsin Yang James

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is the standard therapy for advanced lung adenocarcinomas with common EGFR mutations. Preclinical studies have suggested that uncommon G719X, L861Q, and S768I mutations are also sensitive to EGFR-TKIs. However, the...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Disease-Free Survival
ErbB Receptors
Erlotinib Hydrochloride
Female
Gefitinib

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Protein Kinase Inhibitors

Quinazolines

Survival Rate

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 25668120
DOI: 10.1097/JTO.0000000000000504

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25668120-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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