Article
[Effectiveness of Tyrosine Kinase Inhibitors on Uncommon Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 1 Aug 2015
Yang Xue, Chen Hanxiao, Zhang Hong, Duan Jianchun, An Tongtong, Zhao Jun, Zhuo Minglei, Wu Meina, Wang Jie
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations occur more frequently in non-small cell lung cancer (NSCLC) of women, never smokers, Asian population and those with adenocarcinoma. Short in-frame deletion in exon 19 and L858R substitution are the most common mutations, which are closely associated with EGFR tyrosine kinase inhibitors (TKIs) treatment response. However, the therapeutic effects of...
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