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Mitochondrial permeability transition increases reactive oxygen species production and induces DNA fragmentation in human spermatozoa

5 Feb 2015

Abstract excerpt

STUDY QUESTION: Does mitochondrial permeability transition (MPT) induced by calcium overload cause reactive oxygen species (ROS) production and DNA fragmentation in human spermatozoa? SUMMARY ANSWER: Studies conducted in vitro suggest that in human spermatozoa, MPT occurs in response to intracellular calcium increase and is associated with mitochondrial membrane potential (ΔΨm) dissipation, increased ROS...

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PMID: 25662811
DOI: 10.1093/humrep/dev015

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