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Article

ROS-induced oxidative stress is a major contributor to sperm cryoinjury

27 Nov 2023

Abstract excerpt

STUDY QUESTION: What is the mechanism behind cryoinjury in human sperm, particularly concerning the interplay between reactive oxygen species (ROS) and autophagy, and how does it subsequently affect sperm fate? SUMMARY ANSWER: The freeze-thaw operation induces oxidative stress by generating abundant ROS, which impairs sperm motility and activates autophagy, ultimately guiding the sperm toward programmed cell...

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PMID: 38011909
DOI: 10.1093/humrep/dead250

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