Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy is activated in human spermatozoa subjected to oxidative stress and its inhibition impairs sperm quality and promotes cell death

27 Jan 2022

Abstract excerpt

STUDY QUESTION: Does oxidative stress (OS) activate autophagy in human sperm? SUMMARY ANSWER: Human spermatozoa subjected to OS activate an autophagic response. WHAT IS KNOWN ALREADY: Autophagy is a regulated pathway of lysosomal degradation which helps eukaryotic cells to maintain or restore homeostasis, being a cellular stress response mechanism. OS is a main cause of impaired sperm function and is linked to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cell death mechanisms and regulation
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35137097
DOI: 10.1093/humrep/deac021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy is activated in human spermatozoa subjected to oxidative stress and its inhibition impairs sperm quality and promotes cell deathPMID 35137097Read ↗

Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motilitySemantic proximity Read ↗

Activation of autophagy is required for clearance of mitochondrial ROS in patients with asthenozoospermiaSemantic proximity Read ↗

ROS-induced oxidative stress is a major contributor to sperm cryoinjurySemantic proximity Read ↗

The constructive and destructive impact of autophagy on both genders’ reproducibility, a comprehensive reviewSemantic proximity Read ↗

Mitophagy and spermatogenesis: Role and mechanismsSemantic proximity Read ↗

Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ FertilitySemantic proximity Read ↗

Pathophysiology of Mitochondrial Dysfunction in Human Spermatozoa: Focus on Energetic Metabolism, Oxidative Stress and ApoptosisSemantic proximity Read ↗

Sperm Oxidative Stress during In Vitro Manipulation and Its Effects on Sperm Function and Embryo DevelopmentSemantic proximity Read ↗

Impacts of Oxidative Stress and Antioxidants on Semen FunctionsSemantic proximity Read ↗

Molecular Changes Induced by Oxidative Stress that Impair Human Sperm MotilitySemantic proximity Read ↗

Autophagy: a multifaceted player in the fate of spermSemantic proximity Read ↗

The Autophagy Marker LC3 Is Processed during the Sperm Capacitation and the Acrosome Reaction and Translocates to the Acrosome Where It Colocalizes with the Acrosomal Membranes in Horse SpermatozoaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.