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Mitochondrial membrane potential disruption pattern in human sperm

22 May 2009

Abstract excerpt

BACKGROUND: Loss of mitochondrial membrane potential (DeltaPsi(m)) in spermatozoa is correlated with high levels of reactive oxygen species in semen, abnormal spermiogram parameters, and low success rates of IVF. In somatic cells, the loss of DeltaPsi(m) is primarily associated with several mechanisms of cell death, mainly the activation of caspases. The impact of mitochondrial dysfunction on sperm function is...

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PMID: 19465458
DOI: 10.1093/humrep/dep120

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