Changes in <scp>mRNA</scp> expression precede changes in micro <scp>RNA</scp> expression in lesional psoriatic skin during treatment with adalimumab

Abstract excerpt

BACKGROUND: Tumour necrosis factor (TNF)-α inhibition is an effective treatment for moderate to severe plaque-type psoriasis. A change in the cytokine expression profile occurs in the skin after 4 days of treatment, preceding any clinical or histological improvements. MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression, but miRNA expression has never been studied in psoriatic skin...

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