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Article

Genetic polymorphisms altering micro<scp>RNA</scp> activity in psoriasis – a key to solve the puzzle of missing heritability?

10 Jun 2014

Abstract excerpt

Psoriasis is a chronic immune-mediated skin disease in which the balance in the interplay of immune cells and keratinocytes is disturbed. MicroRNAs (miRNAs) are endogenous small regulatory RNAs that stabilize cellular phenotypes and fine-tune signal transduction feedback loops through the regulation of gene networks. Through the regulation of their multiple target genes, miRNAs regulate the development of...

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PMID: 24917490
DOI: 10.1111/exd.12469

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