Article
Sebaceous gland, hair shaft, and epidermal barrier abnormalities in keratosis pilaris with and without filaggrin deficiency.
The American journal of pathology - 1 Apr 2015
Gruber Robert, Sugarman Jeffrey L, Crumrine Debra, Hupe Melanie, Mauro Theodora M, Mauldin Elizabeth A, Thyssen Jacob P, Brandner Johanna M, Hennies Hans-Christian, Schmuth Matthias, Elias Peter M
Abstract excerpt
Although keratosis pilaris (KP) is common, its etiopathogenesis remains unknown. KP is associated clinically with ichthyosis vulgaris and atopic dermatitis and molecular genetically with filaggrin-null mutations. In 20 KP patients and 20 matched controls, we assessed the filaggrin and claudin 1 genotypes, the phenotypes by dermatoscopy, and the morphology by light and transmission electron microscopy. Thirty-five...
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