ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts.

doi:10.1016/j.placenta.2015.01.010

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ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts.

Placenta - 1 Apr 2015

Thulluru H K, Michel O J, Oudejans C B M, van Dijk M

Abstract excerpt

INTRODUCTION: Pre-eclampsia is a pregnancy-specific disorder and characterized by reduced trophoblast invasion and reduced spiral artery remodeling in the first trimester placenta. A polymorphism located in the promoter region of ACVR2A (rs1424954 (A > G)) has previously been shown to be significantly associated with pre-eclampsia. METHODS: The effects of this variant on ACVR2A expression and its function in the...

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PMID: 25659497
DOI: 10.1016/j.placenta.2015.01.010

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