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Article

Translating Antisense Technology into a Treatment for Huntington's Disease.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Lane Roger M, Smith Anne, Baumann Tiffany, Gleichmann Marc, Norris Dan, Bennett C Frank, Kordasiewicz Holly

Abstract excerpt

Advances in molecular biology and genetics have been used to elucidate the fundamental genetic mechanisms underlying central nervous system (CNS) diseases, yet disease-modifying therapies are currently unavailable for most CNS conditions. Antisense oligonucleotides (ASOs) are synthetic single stranded chains of nucleic acids that bind to a specific sequence on ribonucleic acid (RNA) and regulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29856033
DOI: 10.1007/978-1-4939-7825-0_23

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HTT

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