Article
A novel point-of-care system for high-speed real-time polymerase chain reaction testing for epidermal growth factor receptor mutations in bronchial lavage fluids after transbronchial biopsy in patients with non-small cell lung cancer.
International journal of oncology - 1 Apr 2015
Sakamoto Tomohiro, Kodani Masahiro, Takata Miyako, Chikumi Hiroki, Nakamoto Masaki, Nishii-Ito Shizuka, Ueda Yasuto, Izumi Hiroki, Makino Haruhiko, Touge Hirokazu, Takeda Kenichi, Yamasaki Akira, Yanai Masaaki, Tanaka Natsumi, Igishi Tadashi, Shimizu Eiji
Abstract excerpt
Epidermal growth factor receptor (EGFR) gene mutation testing is essential for choosing appropriate treatment options in patients with advanced non-small cell lung cancer (NSCLC). However, a time delay occurs between histological diagnosis and molecular diagnosis in clinical situations. To minimize this delay, we developed a novel point-of-care test for EGFR mutations, based on a high-speed real-time polymerase...
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