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Article

Rapid point-of-care testing for epidermal growth factor receptor gene mutations in patients with lung cancer using cell-free DNA from cytology specimen supernatants.

International journal of oncology - 1 Jun 2018

Asaka Shiho, Yoshizawa Akihiko, Saito Kazusa, Kobayashi Yukihiro, Yamamoto Hiroshi, Negishi Tatsuya, Nakata Rie, Matsuda Kazuyuki, Yamaguchi Akemi, Honda Takayuki

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutations are associated with responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in non-small-cell lung cancer (NSCLC). Our previous study revealed a rapid point-of-care system for detecting EGFR mutations. This system analyzes cell pellets from cytology specimens using droplet-polymerase chain reaction (d-PCR), and has a reaction time of 10 min. The present study...

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PMID: 29620164
DOI: 10.3892/ijo.2018.4334

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EGFR

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