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Article

miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells

3 Feb 2015

Abstract excerpt

Human telomerase reverse transcriptase (hTERT) plays a crucial role in cancer development. We previously identified paired-like homeodomain1 (PITX1) as an hTERT suppressor gene. However, the underlying mechanisms that are involved in the regulation of PITX1 remain unknown. Here, we report that the microRNA-19b (miR-19b) regulates hTERT expression and cell proliferation through inhibition of PITX1. Compared with...

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PMID: 25643913
DOI: 10.1038/srep08201

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