Article
Single-tube nonaplex microsatellite PCR panel for preimplantation genetic diagnosis of Hb Bart's hydrops fetalis syndrome.
Prenatal diagnosis - 1 Jun 2015
Chen Min, Chan Jerry K Y, Nadarajah Sadhana, Tan Arnold S C, Chan Melinda L H, Mathew Joyce, Saw Eugene E L, Lim Cheryl, Wong Wendy, Cheah Felicia S H, Law Hai-Yang, Wong Peng-Cheang, Chong Samuel S
Abstract excerpt
OBJECTIVE: To develop a single-tube multi-marker assay for improved preimplantation genetic diagnosis (PGD) of deletional and/or non-deletional Hb Bart's hydrops fetalis syndrome, providing haplotype confirmation of deletional status, and maximization of linkage informativity. METHODS: We performed in silico mining to identify novel microsatellites within 1 Mb flanking the alpha-globin gene cluster, and optimized...
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