Article
Splicing is an alternate oncogenic pathway activation mechanism in glioma.
Nature communications - 31 Jan 2022
Siddaway Robert, Milos Scott, Vadivel Arun Kumaran Anguraj, Dobson Tara H W, Swaminathan Jyothishmathi, Ryall Scott, Pajovic Sanja, Patel Palak G, Nazarian Javad, Becher Oren, Brudno Michael, Ramani Arun, Gopalakrishnan Vidya, Hawkins Cynthia
Abstract excerpt
High-grade diffuse glioma (HGG) is the leading cause of brain tumour death. While the genetic drivers of HGG have been well described, targeting these has thus far had little impact on survival suggesting other mechanisms are at play. Here we interrogate the alternative splicing landscape of pediatric and adult HGG through multi-omic analyses, uncovering an increased splicing burden compared with normal brain....
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