Article
Cell fusion between gastric epithelial cells and mesenchymal stem cells results in epithelial-to-mesenchymal transition and malignant transformation.
BMC cancer - 30 Jan 2015
He Xianghui, Li Baosong, Shao Yang, Zhao Na, Hsu Yiling, Zhang Zhixiang, Zhu Liwei
Abstract excerpt
BACKGROUND: The discovery of cancer stem cells and tumor heterogeneity prompted the exploration of additional mechanisms aside from genetic mutations for carcinogenesis and cancer progression. The aim of the present study was to investigate the effect of cell fusion between mesenchymal stem cells and the gastric epithelial cells in tumorigenesis. METHODS: Cell fusion between cord blood mesenchymal stem cells and...
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