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Article

Early Growth Response 3 regulates genes of inflammation and directly activates IL6 and IL8 expression in prostate cancer

29 Jan 2015

Abstract excerpt

BACKGROUND: Transcription factor EGR3 (Early Growth Response 3) is a little-studied member of the EGR family that is highly expressed in human prostate tumours compared with normal tissue. Its function in prostate cancer, however, is unknown. METHODS: Stable shRNA silencing was achieved in naturally overexpressing prostate cancer cells, followed by Affymetrix expression analysis. Fold changes of ⩾2 and ⩽-2 were...

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PMID: 25633035
DOI: 10.1038/bjc.2014.622

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