Accelerated telomere shortening in β-thalassemia/HbE patients.

Abstract excerpt

β-Thalassemia/HbE disease is caused by a defective β-globin synthesis that leads to accumulation of excess unbound α-globins, and consequently oxidative stress, ineffective erythropoiesis and chronic anemia. Cell replication and oxidative stress are factors contributing to erosion of telomeres responsible for maintaining genomic stability and cell replication capability. In this study, the rate of telomere...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to alpha-Globins
• Share to beta-Globins
• Share to beta-Thalassemia