A mechanism of ineffective erythropoiesis in -thalassemia/Hb E disease

Abstract excerpt

BACKGROUND: Cells respond to stress stimuli through a number of response pathways, of which one of the most important and well characterized is the unfolded protein response. Despite a large body of work which suggests that stress in erythroblasts may play a pivotal role in the pathogenesis of beta-thalassemia/Hb E disease, this pathway remains uninvestigated. DESIGN AND METHODS: Day 10 erythroblasts from normal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endoplasmic Reticulum Stress and Disease
• Share to Erythrocyte Function and Pathophysiology
• Share to Hemoglobinopathies and Related Disorders