Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ageing and neurotrophic signalling effects on diaphragm neuromuscular function.

The Journal of physiology - 15 Jan 2015

Greising Sarah M, Ermilov Leonid G, Sieck Gary C, Mantilla Carlos B

Abstract excerpt

The age-related mechanisms underlying sarcopenia are largely unknown. We hypothesize that age-related neuromuscular changes depend on brain-derived neurotrophic factor (BDNF) acting through the tropomyosin-related kinase receptor B (TrkB). Maximal specific force and neuromuscular transmission fai...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Brain-Derived Neurotrophic Factor
Share to Diaphragm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Pyrazoles

Share to Pyrimidines

Share to Receptor, trkB

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 25630263
DOI: 10.1113/jphysiol.2014.282244
PMCID: PMC4303387

Genes

BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25630263-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ageing and neurotrophic signalling effects on diaphragm neuromuscular function.PMID 25630263Read ↗

Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseasesSemantic proximity Read ↗

Sexually dimorphic myofilament function in a mouse model of nemaline myopathy.Semantic proximity Read ↗

Running and swimming prevent the deregulation of the BDNF/TrkB neurotrophic signalling at the neuromuscular junction in mice with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Human neuromuscular structure and function in old age: A brief reviewSemantic proximity Read ↗

Inhibition of protein tyrosine phosphatase PTP1B function ameliorates pathophysiological deficits in Rett SyndromeSemantic proximity Read ↗

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.Semantic proximity Read ↗

TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection.Semantic proximity Read ↗

Invited review: Mechanisms underlying motor unit plasticity in the respiratory system.Semantic proximity Read ↗

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation.Semantic proximity Read ↗

Neuromuscular junction transmission failure is a late phenotype in aging mice.Semantic proximity Read ↗

Ageing in the autonomic nervous system: a result of nerve-target interactions? A review.Semantic proximity Read ↗

Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragmSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.