[Gastrointestinal stromal tumors: a rare nosological entity and a model example for the use of personalized therapy with a molecular basis].

Abstract excerpt

GIST (gastrointestinal stromal tumor) are stromal tumors of the gastrointestinal tract, belonging to a category of rare tumor called soft tissue sarcoma deriving from the Cajal mesenchymal cells. GIST present a peculiar immunohistochemical profile that is indispensable for a diagnostic confirmation: approximately 80% of cases present a mutation of the c-kit gene which codifies for a trans membrane receptor...

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