Article
(-)-epigallocatechin-3-gallate inhibits fibrillogenesis of chicken cystatin.
Journal of agricultural and food chemistry - 11 Feb 2015
Wang Na, He Jianwei, Chang Alan K, Wang Yu, Xu Linan, Chong Xiaoying, Lu Xian, Sun Yonghui, Xia Xichun, Li Hui, Zhang Bing, Song Youtao, Kato Akio, Jones Gary W
Abstract excerpt
Previous studies have reported that (-)-epigallocatechin-3-gallate (EGCG), the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils. To elucidate whether this antifibril activity is specific to disease-related target proteins or is more generic, we investigated the ability of EGCG to inhibit amyloid fibril formation of amyloidogenic mutant...
Topics
- Amyloid
- Animals
- Catechin
- Chickens
- Cystatins
- Molecular Docking Simulation
- Mutation
- Protein Binding
- Protein Structure, Secondary