Article
Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.
Molecules (Basel, Switzerland) - 26 Nov 2020
S Udhaya Kumar, Sankar Srivarshini, Younes Salma, D Thirumal Kumar, Ahmad Muneera Naseer, Okashah Sarah Samer, Kamaraj Balu, Al-Subaie Abeer Mohammed, C George Priya Doss, Zayed Hatem
Abstract excerpt
Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved isoforms in mammals: FLNA, FLNB, and FLNC. FLNB is a multidomain monomer protein with domains containing an actin-binding N-terminal domain (ABD 1-242), encompassing two calponin-homology...
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