Article
Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization.
Cancer causes & control : CCC - 1 Mar 2015
Passarelli Michael N, Newcomb Polly A, Makar Karen W, Burnett-Hartman Andrea N, Potter John D, Upton Melissa P, Zhu Lee-Ching, Rosenfeld Michael E, Schwartz Stephen M, Rutter Carolyn M
Abstract excerpt
PURPOSE: Studies linking cholesterol levels to the development of colorectal neoplasia are inconsistent, and Mendelian randomization has been suggested as a way to help avoid problems with confounding and reverse causation. METHODS: We genotyped individuals who received a colonoscopy at Group Health (1998-2007) for 96 of 102 single-nucleotide polymorphisms identified by the Global Lipids Genetics Consortium....
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