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Article

Chronic stress elevates telomerase activity in rats

10 Oct 2012

Abstract excerpt

The enzyme telomerase lengthens telomeres-protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the...

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Identifiers

PMID: 23054915
DOI: 10.1098/rsbl.2012.0747

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