Article
p53 reactivating small molecule PRIMA‑1MET/APR‑246 regulates genomic instability in MDA‑MB‑231 cells.
Oncology reports - 1 Apr 2022
Amirtharaj Francis, Venkatesh Goutham Hassan, Wojtas Bartosz, Nawafleh Hussam Hussein, Mahmood Ayda Shah, Nizami Zohra Nausheen, Khan Munazza Samar, Thiery Jerome, Chouaib Salem
Abstract excerpt
Pharmacological reactivation of tumor‑suppressor protein p53 has acted as a promising strategy for more than 50% of human cancers that carry a non‑functional mutant p53 (mutp53). p53 plays a critical role in preserving genomic integrity and DNA fidelity through numerous biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis. By contrast, non‑functional mutp53 compromises the...
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