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Article

MicroRNA-520g confers drug resistance by regulating p21 expression in colorectal cancer.

The Journal of biological chemistry - 6 Mar 2015

Zhang Yang, Geng Liying, Talmon Geoffrey, Wang Jing

Abstract excerpt

Development of drug resistance is one of the major causes of colorectal cancer recurrence, yet mechanistic understanding and therapeutic options remain limited. Here, we show that expression of microRNA (miR)-520g is correlated with drug resistance of colon cancer cells. Ectopic expression of miR-520g conferred resistance to 5-fluorouracil (5-FU)- or oxaliplatin-induced apoptosis in vitro and reduced the...

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Identifiers

PMID: 25616665
DOI: 10.1074/jbc.M114.620252
PMCID: PMC4358260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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