Article
The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila.
Aging - 1 Jan 2015
Landis Gary N, Salomon Matthew P, Keroles Daniel, Brookes Nicholas, Sekimura Troy, Tower John
Abstract excerpt
Mating causes decreased life span in female Drosophila. Here we report that mifepristone blocked this effect, yielding life span increases up to +68%. Drug was fed to females after mating, in the absence of males, demonstrating function in females. Mifepristone did not increase life span of virgi...
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