Article
BRAF wild-type melanoma in situ arising in a BRAF V600E mutant dysplastic nevus.
JAMA dermatology - 1 Apr 2015
Tan Jean-Marie, Lin Lynlee L, Lambie Duncan, Flewell-Smith Ross, Jagirdar Kasturee, Schaider Helmut, Sturm Richard A, Prow Tarl W, Soyer H Peter
Abstract excerpt
IMPORTANCE: The BRAF V600E mutation accounts for the majority of BRAF mutations found in cutaneous melanoma and is also commonly found in nevi. We used dermoscopy-targeted sampling and a microbiopsy device coupled with DNA sequence analysis to highlight BRAF V600E heterogeneity within a multicomponent melanocytic proliferation. This sampling technique demonstrates the prospect of in vivo application in a clinical...
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