Article
Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM.
Scientific reports - 21 Jan 2015
Biswas Nidhan K, Chandra Vikas, Sarkar-Roy Neeta, Das Tapojyoti, Bhattacharya Rabindra N, Tripathy Laxmi N, Basu Sunandan K, Kumar Shantanu, Das Subrata, Chatterjee Ankita, Mukherjee Ankur, Basu Pryiadarshi, Maitra Arindam, Chattopadhyay Ansuman, Basu Analabha, Dhara Surajit
Abstract excerpt
Neoplastic cells of Glioblastoma multiforme (GBM) may or may not show sustained response to temozolomide (TMZ) chemotherapy. We hypothesize that TMZ chemotherapy response in GBM is predetermined in its neoplastic clones via a specific set of mutations that alter relevant pathways. We describe exome-wide enrichment of variant allele frequencies (VAFs) in neurospheres displaying contrasting phenotypes of sustained...
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